TEK anticorps (Extracellular Domain)

N° du produit ABIN115159

Cet anticorps Souris Monoclonal détecte spécifiquement TEK dans WB, FACS, IHC (fro) et EIA. Il présente une réactivité envers Humain.

Aperçu rapide pour TEK anticorps (Extracellular Domain) (ABIN115159)

Antigène: TEK (TEK Tyrosine Kinase, Endothelial (TEK))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TEK est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Clone: Cl-16

Détail du produit anti-TEK anticorps

Épitope: Extracellular Domain

Specificité: The monoclonal antibody will detect native Human TIE-2/tek in ELISA experiments and on the surface of different cell types.

Purification: Protein G Affinity Chromatoghraphy

Immunogène: Recombinant Human soluble extracellular TIE-2 protein

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1-15 μg/mL. Western blotting: 1-2 μg/mL. Flow cytometry and cell sorting (FACS): 2-5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Reconstitution: Restore in sterile water to a concentration of 0.1-1.0 mg/mL.

Buffer: PBS, pH 7.4, without preservatives

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles!

Stock: 4 °C/-20 °C

Stockage commentaire: The lyophilized antibody, thought stable at room temperature, is best stored desiccated below 0 °C. Reconstituted anti-TIE-2/tek is stable at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur TEK

Antigène: TEK (TEK Tyrosine Kinase, Endothelial (TEK))

Autre désignation: CD202b / TEK

Sujet: TIE2 (tyrosine kinase with Ig and EGF homology domains 2) is expressed almost exclusively in endothelial cells in mice, rats and humans. This receptor possesses a unique extracellular domain containing two immunoglobulin like loops separated by three epidermal growth factor like repeats that are connected to three fibronectin type III like repeats. The ligand for the receptor is Angiopoietin 1. Defects in TIE2 are associated with inherited venous malformations, the TIE2 signaling pathway appears to be critical for endothelial cell smooth muscle cell communication in venous morphogenesis.Synonyms: Angiopoietin-1 receptor, TIE-2, TIE2, Tunica interna endothelial cell kinase, Tyrosine-protein kinase receptor TEK, Tyrosine-protein kinase receptor TIE-2, p140 TEK

ID gène: 7010

NCBI Accession: NP_000450

UniProt: Q02763

Pathways: Signalisation RTK, Growth Factor Binding